Cyclic phosphodiesterase
WebCyclic-AMP is broken down by an enzyme called cAMP-dependent phosphodiesterase (PDE). The isoform of this enzyme that is targeted by currently used clinical drugs is the type 3 form (PDE3). Inhibition of this enzyme prevents cAMP breakdown and thereby increases its intracellular concentration .
Cyclic phosphodiesterase
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WebThe protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in … WebA phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype (s).
WebcAMP-specific 3',5'-cyclic phosphodiesterase 4D Gene PDE4D Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 809 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Align Add a publication Entry feedback Function WebPDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as smooth muscle contraction and relaxation. For this reason, inhibition of the enzyme can alter those pathophysiological conditions associated with a lowering cGMP level in tissues.
WebAug 22, 2003 · Cyclic GMP phosphodiesterases and regulation of smooth muscle function Cyclic GMP (cGMP) made in response to atrial natriuretic peptide (ANP) or nitric oxide (NO) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug treatment or proliferative signals. WebHTNB is caused by gain-of-function mutations in the phosphodiesterase 3A ( PDE3A) gene. The mutant enzymes are hyperactive. PDE3A (phosphodiesterase 3A) hydrolyzes and thereby terminates cyclic adenosine monophosphate signaling in defined cellular compartments. The cardioprotective effect involves local changes of cyclic adenosine …
WebPhosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.
WebFunction. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes ( PubMed: 15260978 ). May be involved in … mighty ducks movie posterWebIntroduction: PDEs are key enzymes in the adenosine and guanosine cyclic nucleotides (cAMP and cGMP) signaling cascade. Their inhibition increases cyclic nucleotide levels inside the cell. Thus, pharmacological modulation of PDE activity can have profound effects on the function of cells and organ systems throughout the body. new treatments for bunionsWebMar 29, 2024 · Summary The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and … new treatments for chronic painWebEvaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as … new treatments for chronic sinusitisWebFeb 15, 1999 · Caffeine--the drug that gives coffee and cola its kick--has a number of physiological effects. At the cellular level, caffeine blocks the action of a chemical called phosphodiesterase (PDE).... new treatments for chronic prostatitisWebCyclic GMP (cGMP) phosphodiesterase (Pde) is an important enzyme in the process of phototransduction. During phototransduction the 11-cis retinal absorbs a single photon … mighty ducks movie yearThe cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. See more A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. … See more The PDE nomenclature signifies the PDE family with an Arabic numeral, then a capital letter denotes the gene in that family, and a second and final Arabic numeral then indicates the splice variant derived from a single gene (e.g., PDE1C3: family 1, gene C, … See more • Phosphoric+Diester+Hydrolases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more These multiple forms (isoforms or subtypes) of phosphodiesterase were isolated from rat brain using polyacrylamide gel electrophoresis in the early 1970s by See more Phosphodiesterase enzymes have been shown to be different in different types of cells, including normal and leukemic lymphocytes and … See more new treatments for chronic depression