WebDec 1, 2024 · Zhang et al. found that irisin reduced ROS level, iron content, MDA level, increased GSH level in mice, and adjusted the expression of GPX4 and ACSL4 to reduce ferroptosis. In the process of the study, irisin also inhibited ROS accumulation and iron content increase in HK-2 cells. And improve the function of mitochondria [51]. WebIrisin, an exercise‐induced hormone, improves mitochondrial function and reduces reactive oxygen species (ROS) production. Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis and...
Post-treatment With Irisin Attenuates Acute Kidney Injury …
WebJun 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis in the pathogenesis of... WebMay 25, 2024 · Ferroptosis is an iron-dependent, nonapoptotic cell death method characterized by abnormal accumulation of lipid hydroperoxide and related lipophilic reactive oxygen species (ROS) in the cell membrane [ 7, … tarang 1984
Postconditioning with Irisin Attenuates Lung …
WebMay 12, 2024 · Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). WebSep 25, 2024 · We observed that irisin can augment ferroptosis-associated increases in free iron concentrations, lipid peroxide levels, and GSH depletion, while increasing the … WebIrisin, a proteolytic cleavage product of fibronectin type III domain- containingprotein5(FNDC5),isarecentlycharacterizedmulti-func- tional myokine with hormonal actions that is highly expressed in muscle, heart, and adipose tissues and that is released from myocytes in response to exercise.7Irisin has been reported to be involved … tarang ads